Glycodendritic structures as DC-SIGN binders to inhibit viral infections

Glycodendritic structures: tools to interact with DC-SIGN

Javier Rojo received a BSc in Organic Chemistry in 1989, MSc degree in 1990 at the Autónoma University (UAM), Madrid (Spain). Then, he was embarked in the doctoral program to obtain a PhD degree under the supervision of Prof. Juan Carlos Carretero at UAM in 1995. He was a postdoctoral fellow with Prof. Jean-Marie Lehn at the University Louis Pasteur in Strasbourg (France) (19951998) and with Pr...

Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans.

We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of micro...

Human Dendritic Cells for the Induction of Glycoprotein Binding and Deliver Antigen to Lectins, L-SIGN and DC-SIGN, Inhibit Viral Internalizing Antibodies to the C-Type

Glycodendritic structures: promising new antiviral drugs.

DC-SIGN, a C-type lectin expressed by dendritic cells, is able to recognize high mannosylated glycoproteins at the surface of a broad range of pathogens including viruses, bacteria, fungi and parasites. For at least some of these agents this interaction appears to be an important part of the infection process. Therefore, this lectin might be considered in the design of new antiviral drugs. In t...

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants

DC-SIGN, a C-type lectin mainly expressed by DCs, mediates antigen uptake and can induce specific immune responses, depending on the ligand involved. Owing to these properties, DC-SIGN is an attracting target for approaches aimed at tailoring the immune response towards specific immunologic outcomes. A multivalent DC-SIGN ligand (Polyman26), containing at its core a fluorescent "rod-like" space...